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Biophysics, v 54 N.1, p.47-50, 2009

Nonlinear nature of the antiarrhythmic effects of the lidocaine
(in version of author's manuscript)

A.V. Moskalenko

Institute for Theoretical & Experimental Biophysics, Pushchino, Moscow Region, 142290 Russia

For the first time evidence of nonlinear dependence of antiarrhythmic effect of the Na-channel blockator on its concentration was obtained in experiments. The experiments were carried out with a use of preparation of mammal heart wall. As a blockator, the lidocain was used. It was ascertained that the dependence of antiarrhythmic effect of the lidocain on its concentration have strongly pronounced nonlinear nature: While its therapeutic concentration make ventricular arrhythmias be more monomorphic, little concentration of lidocain increases the probability for the arrhythmias to appear more polymorphic.

Key words: ventricular tachycardia, normalized-value analysis of electrocardiographic variability, antiarrhythmic drug, blockade of sodium channels

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DISCUSSION

Our results well agree with the results of theoretical investigation described in [5] as well as in [12].

Thus it must be concluded that little concentrations of the lidocaine raise the probability of polymorphic tachycardia while its greater concentrations suppress the excitability of heart tissue too much for the heart to can work efficiently. Probably the conclusion is correct and for the other blockaders of sodium channels.

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REFERENCES

1. Medvinskiy A.B., Kukushkin N.I. // Vestnik aritmologii, 2004;(35):49-55.

2. Cardiac Arrhythmias, Ed. by W. J. Mandel. JB Lippincott, Philadelphia, 1995.

3. Doshicin V.L. // Rossiyskiy kardiologicheskiy zhurnal, 1999;(1):46-51.

4. Golicyn S.P. // Serdechnaia nedostatochnost', 2001;2(5):201-208.

5. Efimov, I.R., Krinsky, V.I., Jalife, J. // Chaos, Solitons and Fractals, 1995;(5):513–526.

6.Moskalenko A.V., Kukushkin N.I., Starmer C.F., Deev A.A., Kukushkina K.N., Medvinsky A.B. // Biophysics, 2001;46(2):313-323.

7. Moskalenko A.V., Elkin Yu.E. // Chaos, Solitons and Fractals, 2008;(1):66–72. DOI link: 10.1016/j.chaos.2006.06.009

8. Kukushkin N.I., Sidorov V.YU., K.N. Gorbacheva, A.V. Savin. // Vestnik aritmologii, 2004;(37):47-56.

9. Kukushkin N.I., Sidorov V.YU., Medvinskiy A.B., Romashko D.N., Burashnikov A.IU., Starmer CH.F., Sarancha D.Yu., Baum O.V. // Biofizika, 1998;43(6):1043-1059.

10.Sarancha D.Yu., Medvinsky A.B., Kukushkin N.I., Sidorov V.Yu., Romashko D.N., Burashnikov A.Yu., Moskalenko A.V., Starmer C.F. // Biophysics, 1997;42(2):491-496.

11. Moskalenko A.V., Medvinsky A.B., Tikhonova I.A., Sidorov V.Yu., Kukushkin N.I., Starmer C.F. Automatized working place for researcher on an example of the plant for multielectrode mapping of myocardium. // Proceedings of the VI conference "Mathematics. Computer. Education". Pushchino, Moscow, Progress-Tradition, p.131-134, 1999 (In Russian).

12. Winfree A. // Chaos, 1991;1(3):303–334.

FIGURES


Fig.1. Effect of lidocaine on distribution of the experimental ventricular arrhythmias by the degree of polymorphism. Horizontal datum is the index V1i, vertical - sample probability. In the upper right corner of every sample histogram, it is indicated an experiment phase and values of conditional probability of arrhythmias with V1i lager than the value stated.

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Fig.1
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Fig.2. Distribution of the experimental ventricular arrhythmias by the degree of polymorphism in dependence of experiment duration. Notation is the same as in Fig. 1.

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Fig.2
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Fig.3. Conditional probability of arrhythmias with V1i lager than the value stated (see the legend) in dependence on the lidocaine concentration in the physiological solution (generalization of Fig. 1).

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Fig.3