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Submited on the 29th Jan. 2007.
Rejected by prof. Jim Keener ("Mathematical Medicine and Biology: A Journal of the IMA") on the 12th March 2007.

A new mechanism of spontaneous transition from polymorphic to monomorphic arrhythmia in a mathematical model of cardiac tissue dynamics

A.V. Moskalenko*), Yu. E. Elkin**) ***)

*)Institute for Theoretical & Experimental Biophysics RAS

**)Institute of Mathematical Problems of Biology RAS

***) Pushchino Branch of the Moscow State University

We found a new regime of autowave behavior in a homogeneous two-dimensional model of cardiac tissue. At that regime, the spiral wave tip motion transforms from two-periodic meander into the circular rotation due to spontaneous deceleration of spiral wave drift. In cardiology, such autowave behavior transformation could account for spontaneous transformation from polymorphic to monomorphic ventricular arrhythmia in the heart. ECG diagnostics of spiral wave behavior is discussed.

Keywords: cardiac arrhythmia, excitable media, variability of ECG, mathematical modeling, ANI-method, meander, spiral waves

See also: Moskalenko A.V. "Nonlinear and nonstationary ECG analysis of spontaneous transition from polymorphic to monomorphic arrhythmia in a mathematical model of cardiac tissue dynamics". Proceedings of the International Biosignal Processing Conference. Berlin, Germany, 2010: 084:1-4.